How Viagra Works: The Science Behind Sildenafil for ED

Viagra has helped millions of men worldwide. But how does it actually work?

The Science

Viagra belongs to a class of drugs called PDE5 inhibitors. During arousal, the body releases nitric oxide in the penis, triggering cyclic GMP production. This relaxes blood vessels, allowing increased blood flow. Viagra blocks the PDE5 enzyme that breaks down cyclic GMP, sustaining the erection.

Effectiveness

Approximately 70% of men with ED respond positively to Viagra, making it one of the most effective treatments available.


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